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Article

Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model.

PloS one - 1 Jan 2017

Razazan Atefeh, Behravan Javad, Arab Atefeh, Barati Nastaran, Arabi Leila, Gholizadeh Zahra, Hatamipour Mahdi, Reza Nikpoor Amin, Momtazi-Borojeni Amir Abbas, Mosaffa Fatemeh, Ghahremani Mohamad Hosein, Jaafari Mahmoud Reza

Abstract excerpt

One of the challenging issues in vaccine development is peptide and adjuvant delivery into target cells. In this study, we developed a vaccine and therapeutic delivery system to increase cytotoxic T lymphocyte (CTL) response against a breast cancer model overexpressing HER2/neu. Gp2, a HER2/neu-derived peptide, was conjugated to Maleimide-mPEG2000-DSPE micelles and post inserted into liposomes composed of DMPC,...

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Identifiers

PMID: 29045460
DOI: 10.1371/journal.pone.0185099
PMCID: PMC5646774

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MPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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