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Genetically Engineered Cytomembrane Nanovaccines for Cancer Immunotherapy

7 Feb 2024

Abstract excerpt

Cancer nanovaccines have attracted widespread attention by inducing potent cytotoxic T cell responses to improve immune checkpoint blockade (ICB) therapy, while the lack of co-stimulatory molecules limits their clinical applications. Here, a genetically engineered cancer cytomembrane nanovaccine is reported that simultaneously overexpresses co-stimulatory molecule CD40L and immune checkpoint inhibitor PD1 to...

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PMID: 38320299
DOI: 10.1002/adhm.202400068

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