Article
Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy.
Biomaterials - 1 Aug 2018
Zhang Ling-Xiao, Xie Xi-Xiu, Liu Dong-Qun, Xu Zhi Ping, Liu Rui-Tian
Abstract excerpt
Cancer immunotherapy has shown tremendous progresses in recent years for various cancers and layered double hydroxide (LDH) nanoparticles are demonstrated as effective adjuvants for protein-based vaccines. This research further shows that the colloidal stability of LDH-based vaccines significantly influences the therapeutic efficacy and LDH nanoparticles are able to adjuvant multiple tumor-associated antigen...
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