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Article

Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function

23 May 2022

Abstract excerpt

Objective Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ventricular arrhythmias, and cardiomyopathies. The association with anti-Ro/SSA antibodies is well established, but a recurrence rate of only 12%–16% despite persisting maternal autoantibodies...

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PMID: 35470161
DOI: 10.1136/annrheumdis-2021-221714

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