Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors.

Recent patents on endocrine, metabolic & immune drug discovery - 1 Jan 2011

Ulloa-Aguirre Alfredo, Michael Conn P

Abstract excerpt

G Protein-coupled receptors (GPCRs) are cell membrane proteins that recognize specific chemical signals such as drugs and hormones and transduce these signals into cellular responses by activating G-proteins. As is the case for all newly synthesized proteins, GPCRs are subjected to conformational scrutiny at the endoplasmic reticulum prior to processing and trafficking to the cell surface membrane. Because of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Chaperones

Share to Molecular Targeted Therapy

Share to Protein Folding

Share to Protein Transport

Share to Receptors, G-Protein-Coupled

Share to Receptors, LHRH

Source

Open in PubMed Open full text

Identifiers

PMID: 22074574
DOI: 10.2174/187221411794351851
PMCID: PMC3235328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors.PMID 22074574Read ↗

Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules.Semantic proximity Read ↗

Pharmacoperone drugs: targeting misfolded proteins causing lysosomal storage-, ion channels-, and G protein-coupled receptors-associated conformational disorders.Semantic proximity Read ↗

G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo.Semantic proximity Read ↗

Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases.Semantic proximity Read ↗

Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.Semantic proximity Read ↗

Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs.Semantic proximity Read ↗

Pharmacological chaperone action on G-protein-coupled receptors.Semantic proximity Read ↗

Pharmacological chaperones: a new twist on receptor folding.Semantic proximity Read ↗

Protein misfolding diseases: Prospects of pharmacological treatment.Semantic proximity Read ↗

Chaperoning G protein-coupled receptors: from cell biology to therapeutics.Semantic proximity Read ↗

[Pharmacological chaperones: a potential therapeutic treatment for conformational diseases].Semantic proximity Read ↗

Pharmacological chaperone approaches for rescuing GPCR mutants: Current state, challenges, and screening strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.