Article
Using the molecular classification of glioblastoma to inform personalized treatment.
The Journal of pathology - 1 Jan 2014
Olar Adriana, Aldape Kenneth D
Abstract excerpt
Glioblastoma is the most common and most aggressive diffuse glioma, associated with short survival and uniformly fatal outcome, irrespective of treatment. It is characterized by morphological, genetic and gene-expression heterogeneity. The current standard of treatment is maximal surgical resection, followed by radiation, with concurrent and adjuvant chemotherapy. Due to the heterogeneity, most tumours develop...
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