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Article

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity.

Nucleic acids research - 1 Dec 2017

Chan Foong Lyn, Vinod Benjamin, Novy Karel, Schittenhelm Ralf B, Huang Cheng, Udugama Maheshi, Nunez-Iglesias Juan, Lin Jane I, Hii Linda, Chan Julie, Pickett Hilda A, Daly Roger J, Wong Lee H

Abstract excerpt

AURKB (Aurora Kinase B) is a serine/threonine kinase better known for its role at the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1. Loss of AURKB function affects TERF1 telomere binding and results in aberrant telomere structure. In vitro kinase experiments...

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Identifiers

PMID: 29040668
DOI: 10.1093/nar/gkx904
PMCID: PMC5716096

Genes

AURKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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