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Article

Patterns of symptom development in patients with motor neuron disease.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Feb 2018

Walhout Renée, Verstraete Esther, van den Heuvel Martijn P, Veldink Jan H, van den Berg Leonard H

Abstract excerpt

OBJECTIVE: To investigate whether symptom development in motor neuron disease (MND) is a random or organized process. METHODS: Six hundred patients with amyotrophic lateral sclerosis (ALS), upper motor neuron (UMN) or lower motor neuron (LMN) phenotypes were invited for a questionnaire concerning symptom development. A binomial test was used to examine distribution of symptoms from site of onset. Development of...

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PMID: 29037065
DOI: 10.1080/21678421.2017.1386688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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