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Article

Natural History of "Pure" Primary Lateral Sclerosis.

Neurology - 27 Apr 2021

Hassan Anhar, Mittal Shivam Om, Hu William T, Josephs Keith A, Sorenson Eric J, Ahlskog J Eric

Abstract excerpt

OBJECTIVE: To assess whether primary lateral sclerosis (PLS), classified as pure when the EMG is normal, converts to amyotrophic lateral sclerosis (ALS) after longitudinal follow-up. METHODS: Retrospective chart review was performed of patients with pure PLS at Mayo Clinic in Rochester, MN (1990-2016). Inclusion criteria required a normal EMG during the first 4 years of symptoms. RESULTS: Forty-three patients had...

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PMID: 33637635
DOI: 10.1212/WNL.0000000000011771
PMCID: PMC8166429

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