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Article

Amyotrophic lateral sclerosis established as a multistep process across phenotypes.

European journal of neurology - 1 Jan 2025

Ziser Laura, van Eijk Ruben P A, Kiernan Matthew C, McRae Allan, Henderson Robert D, Schultz David, Needham Merrilee, Mathers Susan, McCombe Pam, Talman Paul, Vucic Steve

Abstract excerpt

BACKGROUND AND PURPOSE: Given the accepted multistep process of disease causation in amyotrophic lateral sclerosis (ALS), the present study was undertaken to determine the number of steps required for disease onset across each of the ALS phenotypes. METHODS: Clinical and demographic data were prospectively accumulated using the Australian Motor Neurone Disease Registry (2005-2016), and age-specific incidence...

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Identifiers

PMID: 39475283
DOI: 10.1111/ene.16532
PMCID: PMC11622508

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