Article
Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model.
International journal of environmental research and public health - 15 Oct 2017
de Andrade Mariza, Armasu Sebastian M, McCauley Bryan M, Petterson Tanya M, Heit John A
Abstract excerpt
BACKGROUND: Certain diseases can occur with and without a trigger. We use Venous Thromboembolism (VTE) as our example to identify genetic interaction with pregnancy in women with VTE during pre- or postpartum. Pregnancy is one of the major risk factors for VTE as it accounts for 10% of maternal deaths. METHODS: We performed a whole genome association analysis using the Cox Proportional Hazard (CoxPH) model...
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