Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk.

doi:10.1016/j.jtha.2024.05.011

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Article

Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2024

Hasser Emily K, Brody Jennifer A, Bartz Traci M, Thibord Florian, Li-Gao Ruifang, Kauko Anni, Wiggins Kerri L, Teder-Laving Maris, Kim Jihye, Munsch Gaëlle, Haile Helen G, Deleuze Jean-Francois, van Hylckama Vlieg Astrid, Wolberg Alisa S, Boland Anne, Morange Pierre-Emmanuel, Kraft Peter, Lowenstein Charles J, Emmerich Joseph, Sitlani Colleen M, Suchon Pierre, Rosendaal Frits R, Niiranen Teemu, Kabrhel Christopher, Trégouët David-Alexandre, Smith Nicholas L

Abstract excerpt

BACKGROUND: Increased risk of venous thromboembolism (VTE) is a life-threatening side effect for users of oral contraceptives (OCs) or hormone therapy (HT). OBJECTIVES: To investigate the potential for genetic predisposition to VTE in OC or HT users, we conducted a gene-by-environment case-only meta-analysis of genome-wide association studies (GWAS). METHODS: Use or nonuse of OCs (7 studies) or HT (8 studies) at...

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PMID: 38782299
DOI: 10.1016/j.jtha.2024.05.011

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