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Article

Genetic risk assessment of pregnancy-associated venous thromboembolism: dual utility of maternal peripheral blood in NIPT and VTE evaluation.

BMC pregnancy and childbirth - 6 Jan 2026

Hua Renyi, Yang Zhen, Han Xu, Yang Linfeng, Lin Zhe, Xu Wenqiu, Chen Luyang, Zhang Jianguo, Zhao Lijian, Wang Yanlin

Abstract excerpt

OBJECTIVE: Venous thromboembolism (VTE) is a leading cause of maternal mortality, with pregnancy significantly increasing VTE risk due to physiological hypercoagulability. Current risk assessment methods, such as VTE scoring systems and D-dimer testing, have limitations in identifying high-risk individuals, highlighting the need for improved stratification. METHODS: Whole genome sequencing (WGS) was performed on...

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Identifiers

PMID: 41491418
DOI: 10.1186/s12884-025-08212-9
PMCID: PMC12870445

Genes

C4A
PRSS1
ACE
TUBB1

Variants

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