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Article

FOLD: a method to optimize power in meta-analysis of genetic association studies with overlapping subjects.

Bioinformatics (Oxford, England) - 15 Dec 2017

Kim Emma E, Lee Seunghoon, Lee Cue Hyunkyu, Oh Hyunjung, Song Kyuyoung, Han Buhm

Abstract excerpt

MOTIVATION: In genetic association studies, meta-analyses are widely used to increase the statistical power by aggregating information from multiple studies. In meta-analyses, participating studies often share the same individuals due to the shared use of publicly available control data or accidental recruiting of the same subjects. As such overlapping can inflate false positive rate, overlapping subjects are...

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PMID: 29036405
DOI: 10.1093/bioinformatics/btx463
PMCID: PMC5860085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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