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Article

Improved score statistics for meta-analysis in single-variant and gene-level association studies.

Genetic epidemiology - 1 Jun 2018

Yang Jingjing, Chen Sai, Abecasis Gonçalo

Abstract excerpt

Meta-analysis is now an essential tool for genetic association studies, allowing them to combine large studies and greatly accelerating the pace of genetic discovery. Although the standard meta-analysis methods perform equivalently as the more cumbersome joint analysis under ideal settings, they result in substantial power loss under unbalanced settings with various case-control ratios. Here, we investigate the...

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PMID: 29696691
DOI: 10.1002/gepi.22123
PMCID: PMC5980755

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