Article
Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.
PloS one - 1 Jan 2017
Chan Sze Ling, Chua Angeline Poh Gek, Aminkeng Folefac, Chee Cynthia Bin Eng, Jin Shengnan, Loh Marie, Gan Suay Hong, Wang Yee Tang, Brunham Liam R
Abstract excerpt
BACKGROUND AND AIMS: Isoniazid (INH) is part of the first-line-therapy for tuberculosis (TB) but can cause drug-induced liver injury (DILI). Several candidate single nucleotide polymorphisms (SNPs) have been previously identified but the clinical utility of these SNPs in the prediction of INH-DILI remains uncertain. The aim of this study was to assess the association between selected candidate SNPs and the risk...
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