Article
A Budding-Defective M2 Mutant Exhibits Reduced Membrane Interaction, Insensitivity to Cholesterol, and Perturbed Interdomain Coupling.
Biochemistry - 7 Nov 2017
Herneisen Alice L, Sahu Indra D, McCarrick Robert M, Feix Jimmy B, Lorigan Gary A, Howard Kathleen P
Abstract excerpt
Influenza A M2 is a membrane-associated protein with a C-terminal amphipathic helix that plays a cholesterol-dependent role in viral budding. An M2 mutant with alanine substitutions in the C-terminal amphipathic helix is deficient in viral scission. With the goal of providing atomic-level understanding of how the wild-type protein functions, we used a multipronged site-directed spin labeling electron paramagnetic...
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