Article
Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection.
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2024
Zhang Yijin, Schmick Scott D, Xie Li, Ghosh Ujjayini, Weliky David P
Abstract excerpt
HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion (joining) viral and cell membranes. The HIV Fp is the ~23 N-terminal residues of the gp41 spike protein. Fp adopts intermolecular antiparallel β sheet structure when lipid fraction cholesterol ≈0.3, which is comparable to host cells....
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