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Article

Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.

Journal of molecular biology - 18 Mar 2005

Stouffer Amanda L, Nanda Vikas, Lear James D, DeGrado William F

Abstract excerpt

The driving forces behind the folding processes of integral membrane proteins after insertion into the bilayer, is currently under debate. The M2 protein from the influenza A virus is an ideal system to study lateral association of transmembrane helices. Its proton selective channel is essential for virus functioning and a target of the drug amantadine. A 25 residue transmembrane fragment of M2, M2TM, forms a...

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Identifiers

PMID: 15733926
DOI: 10.1016/j.jmb.2005.01.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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