Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Membrane scission driven by the PROPPIN Atg18.

The EMBO journal - 15 Nov 2017

Gopaldass Navin, Fauvet Bruno, Lashuel Hilal, Roux Aurélien, Mayer Andreas

Abstract excerpt

Sorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane-bound tubulo-vesicular carriers. How scission occurs is poorly understood, but family proteins bind these membranes. Here, we show that the yeast PROPPIN Atg18 carries membrane scission activity. Purified Atg18 drives tubulation and scission of giant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Autophagy-Related Proteins
Share to Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol Phosphates

Share to Protein Multimerization

Share to Sodium Chloride

Share to Time-Lapse Imaging

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 29030482
DOI: 10.15252/embj.201796859
PMCID: PMC5686546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Membrane scission driven by the PROPPIN Atg18.PMID 29030482Read ↗

A conserved ATG2 binding site in WIPI4 and yeast Hsv2 is disrupted by mutations causing β-propeller protein-associated neurodegeneration.Semantic proximity Read ↗

WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanismsSemantic proximity Read ↗

Structure of yeast Ape1 and its role in autophagic vesicle formation.Semantic proximity Read ↗

A PROPPIN links V-ATPase assembly to endocytic membrane dynamics in malaria parasitesSemantic proximity Read ↗

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes.Semantic proximity Read ↗

ATG16L1 membrane recruitment in autophagySemantic proximity Read ↗

Reconstitution of autophagosomal membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimeticsSemantic proximity Read ↗

Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions.Semantic proximity Read ↗

A perspective from transport protein particle: vesicle tether and human diseases.Semantic proximity Read ↗

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosisSemantic proximity Read ↗

Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy inductionSemantic proximity Read ↗

Structural biology of the Atg8 and Atg12 conjugation systemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.