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Article

Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions.

PloS one - 1 Jan 2018

Nguyen Hoa Mai, Liu Shuxian, Daher Wassim, Tan Feng, Besteiro Sébastien

Abstract excerpt

Toxoplasma gondii is a parasitic protist possessing a limited set of proteins involved in the autophagy pathway, a self-degradative machinery for protein and organelle recycling. This distant eukaryote has even repurposed part of this machinery, centered on protein ATG8, for a non-degradative function related to the maintenance of the apicoplast, a parasite-specific organelle. However, some evidence also suggest...

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Identifiers

PMID: 29659619
DOI: 10.1371/journal.pone.0195921
PMCID: PMC5901921

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Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions.PMID 29659619Read ↗

<i>Toxoplasma gondii</i> PROP1 is critical for autophagy and parasite viability during chronic infectionSemantic proximity Read ↗

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Apicoplast biogenesis mediated by ATG8 requires the ATG12–ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondiiSemantic proximity Read ↗

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