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Article

Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.

The Journal of allergy and clinical immunology - 1 Feb 2018

Jensen Elizabeth T, Kuhl Jonathan T, Martin Lisa J, Langefeld Carl D, Dellon Evan S, Rothenberg Marc E

Abstract excerpt

BACKGROUND: Although eosinophilic esophagitis (EoE) is associated with certain gene variants, the rapidly increasing incidence of EoE suggests that environmental factors contribute to disease development. OBJECTIVE: We tested for gene-environment interaction between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13, CAPN14, CCL26, and TGFB) and implicated early-life factors (antibiotic use in infancy,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29029802
DOI: 10.1016/j.jaci.2017.07.010
PMCID: PMC5803324

Genes

CAPN14
KLF13
CCL26
TSLP

Provenance

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