Article
Familial MPN Predisposition.
Current hematologic malignancy reports - 1 Oct 2017
Tashi Tsewang, Swierczek Sabina, Prchal Josef T
Abstract excerpt
Chronic myeloproliferative neoplasms (MPN) characteristically arise from a somatic mutation in the pluripotent hematopoietic stem cell, and most common recurring mutations are in the JAK2, CALR, and cMPL genes. However, these mutations are not founder mutations, but mainly drive the disease phenotype and a pre-existing germline predisposition has been long speculated, but has not been clearly defined to date....
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