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Article

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms.

Blood - 25 Aug 2016

Hinds David A, Barnholt Kimberly E, Mesa Ruben A, Kiefer Amy K, Do Chuong B, Eriksson Nicholas, Mountain Joanna L, Francke Uta, Tung Joyce Y, Nguyen Huong Marie, Zhang Haiyu, Gojenola Linda, Zehnder James L, Gotlib Jason

Abstract excerpt

We conducted a genome-wide association study (GWAS) to identify novel predisposition alleles associated with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) and JAK2 V617F clonal hematopoiesis in the general population. We recruited a web-based cohort of 726 individuals with polycythemia vera, essential thrombocythemia, and myelofibrosis and 252 637 population controls unselected for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27365426
DOI: 10.1182/blood-2015-06-652941
PMCID: PMC5085254

Genes

JAK2
ATM
CHEK2
TERT
TET2

Variants

Provenance

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