Article
Genetic-pathologic characterization of myeloproliferative neoplasms.
Experimental & molecular medicine - 22 Jul 2016
Kim Yonggoo, Park Joonhong, Jo Irene, Lee Gun Dong, Kim Jiyeon, Kwon Ahlm, Choi Hayoung, Jang Woori, Chae Hyojin, Han Kyungja, Eom Ki-Seong, Cho Byung-Sik, Lee Sung-Eun, Yang Jinyoung, Shin Seung-Hwan, Kim Hyunjung, Ko Yoon Ho, Park Haeil, Jin Jong Youl, Lee Seungok, Jekarl Dong Wook, Yahng Seung-Ah, Kim Myungshin
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the proliferation of one or more myeloid lineages. The current study demonstrates that three driver mutations were detected in 82.6% of 407 MPNs with a mutation distribution of JAK2 in 275 (67.6%), CALR in 55 (13.5%) and MPL in 6 (1.5%). The mutations were mutually exclusive in principle except in one patient with...
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