Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.

Scientific reports - 12 Oct 2017

Eichstaedt Christina A, Pagani Luca, Antao Tiago, Inchley Charlotte E, Cardona Alexia, Mörseburg Alexander, Clemente Florian J, Sluckin Timothy J, Metspalu Ene, Mitt Mario, Mägi Reedik, Hudjashov Georgi, Metspalu Mait, Mormina Maru, Jacobs Guy S, Kivisild Toomas

Abstract excerpt

The aim of this study is to identify genetic variants that harbour signatures of recent positive selection and may facilitate physiological adaptations to hypobaric hypoxia. To achieve this, we conducted whole genome sequencing and lung function tests in 19 Argentinean highlanders (>3500 m) comparing them to 16 Native American lowlanders. We developed a new statistical procedure using a combination of population...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Altitude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Argentina

Share to Basic Helix-Loop-Helix Transcription Factors

Share to EPAS1 gene

Share to Gene Frequency

Share to Receptors, G-Protein-Coupled

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29026132
DOI: 10.1038/s41598-017-13382-4
PMCID: PMC5638799

Genes

EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.PMID 29026132Read ↗

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.Semantic proximity Read ↗

Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep.Semantic proximity Read ↗

EPAS1 Gain-of-Function Mutation Contributes to High-Altitude Adaptation in Tibetan HorsesSemantic proximity Read ↗

Sequencing of 50 human exomes reveals adaptation to high altitude.Semantic proximity Read ↗

Andean and Tibetan patterns of adaptation to high altitude.Semantic proximity Read ↗

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice.Semantic proximity Read ↗

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.Semantic proximity Read ↗

Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.Semantic proximity Read ↗

Functional EPAS1 / HIF2A missense variant is associated with hematocrit in Andean highlandersSemantic proximity Read ↗

Evolutionary significance of selected EDAR variants in Tibetan high-altitude adaptations.Semantic proximity Read ↗

High-impact Genetic Variants in EGLN1, EPAS1, and Other Genes Identified in Mountaineers by Exome Sequencing.Semantic proximity Read ↗

Adaptation to High Altitude: Phenotypes and GenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.