Article
miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat.
Cardiovascular research - 1 Jun 2013
Merlet Elise, Atassi Fabrice, Motiani Rajender K, Mougenot Nathalie, Jacquet Adeline, Nadaud Sophie, Capiod Thierry, Trebak Mohamed, Lompré Anne-Marie, Marchand Alexandre
Abstract excerpt
AIMS: Our aim was to identify new microRNAs (miRNAs) implicated in pathological vascular smooth muscle cells (VSMCs) proliferation and characterize their mechanism of action. METHODS AND RESULTS: MicroRNAs microarray and qRT-PCR results lead us to focus on miR-424 or its rat ortholog miR-322 (miR-424/322). In vitro mir-424/322 level was decreased shortly after the induction of proliferation and increased in a...
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