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Article

Germline Pathogenic Variants Identified in Patients With Genitourinary Malignancies Undergoing Universal Testing: A Multisite Single-Institution Prospective Study.

The Journal of urology - 1 Oct 2024

Choudry Mouneeb M, Durant Adri M, Edmonds Victoria S, Warren Christopher J, Kunze Katie L, Golafshar Michael A, Nielsen Sarah M, Esplin Edward D, Andrews Jack R, Samadder N Jewel, Tyson Mark D

Abstract excerpt

PURPOSE: This study aimed to investigate the prevalence of pathogenic germline variants (PGVs) in hereditary cancer genes utilizing a universal testing approach and to determine the rate of PGVs that would have been missed based on National Comprehensive Cancer Network (NCCN) guidelines in genitourinary (GU) malignancies. MATERIALS AND METHODS: A multisite, single-institution prospective germline genetic test...

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Identifiers

PMID: 38860938
DOI: 10.1097/JU.0000000000004089
PMCID: PMC12721686

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