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Article

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016

Vogiatzi Fotini, Brandt Dominique T, Schneikert Jean, Fuchs Jeannette, Grikscheit Katharina, Wanzel Michael, Pavlakis Evangelos, Charles Joël P, Timofeev Oleg, Nist Andrea, Mernberger Marco, Kantelhardt Eva J, Siebolts Udo, Bartel Frank, Jacob Ralf, Rath Ariane, Moll Roland, Grosse Robert, Stiewe Thorsten

Abstract excerpt

Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations inactivate tumor suppression by p53, and some endow the protein with novel gain of function (GOF) properties that actively promote tumor progression and metastasis. By comparative gene expression profiling of...

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Source

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Identifiers

PMID: 27956623
DOI: 10.1073/pnas.1612711114
PMCID: PMC5206569

Genes

ENTPD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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