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Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

25 Aug 2017

Abstract excerpt

Background: Microglia and periphery-derived monocytes infiltrate human and mouse glioblastoma and their density is positively correlated with malignancy. Using microarray and RNA sequencing, we have previously shown that glioblastoma-associated microglia/monocytes (GAMs) express osteopontin/SPP1. Methods: We used quantitative reverse transcriptase PCR, immunofluorescence stainings, western blot, and flow...

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PMID: 29016864
DOI: 10.1093/neuonc/nox165

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