Article
Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension.
Cardiovascular research - 1 Nov 2017
Liang Olin D, So Eui-Young, Egan Pamela C, Goldberg Laura R, Aliotta Jason M, Wu Keith Q, Dubielecka Patrycja M, Ventetuolo Corey E, Reginato Anthony M, Quesenberry Peter J, Klinger James R
Abstract excerpt
AIMS: The pathogenic mechanisms of pulmonary arterial hypertension (PAH) remain unclear, but involve dysfunctional endothelial cells (ECs), dysregulated immunity and inflammation in the lung. We hypothesize that a developmental process called endothelial to haematopoietic transition (EHT) contributes to the pathogenesis of pulmonary hypertension (PH). We sought to determine the role of EHT in mouse models of PH,...
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