Article

Microenvironment-contextual cell signaling is attenuated with age

2019-06-27

Abstract excerpt

Post-menopausal women are more prone to breast cancer than younger women. The increased frequency of age-related breast cancers is likely due to interactions between acquired mutations and age-dependent epigenetic changes that affect mammary epithelial lineage fidelity. We hypothesized that the aging process fundamentally affects how human mammary epithelial cells (HMEC) respond to microenvironmental signals, resu...

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Literature Corpus work: 659fb18c-bc2e-5b5c-95b0-3cba30ecf67d
DOI: 10.1101/684977

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