Article
YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.
The Journal of biological chemistry - 17 Feb 2012
Le Hai-Tuong, Gautier Valérie, Kthiri Fatoum, Malki Abderrahim, Messaoudi Nadia, Mihoub Mouadh, Landoulsi Ahmed, An Young Jun, Cha Sun-Shin, Richarme Gilbert
Abstract excerpt
YajL is the closest Escherichia coli homolog of the Parkinsonism-associated protein DJ-1, a multifunctional oxidative stress response protein whose biochemical function remains unclear. We recently reported the aggregation of proteins in a yajL mutant in an oxidative stress-dependent manner and that YajL exhibits chaperone activity. Here, we show that YajL displays covalent chaperone and weak protein...
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