Article
Brucella abortus Promotes a Fibrotic Phenotype in Hepatic Stellate Cells, with Concomitant Activation of the Autophagy Pathway.
Infection and immunity - 1 Jan 2018
Arriola Benitez Paula Constanza, Pesce Viglietti Ayelén Ivana, Herrmann Claudia Karina, Dennis Vida A, Comerci Diego José, Giambartolomei Guillermo Hernán, Delpino María Victoria
Abstract excerpt
The liver is frequently affected in patients with active brucellosis. The present study demonstrates that Brucella abortus infection induces the activation of the autophagic pathway in hepatic stellate cells to create a microenvironment that promotes a profibrogenic phenotype through the induction of transforming growth factor-β1 (TGF-β1), collagen deposition, and inhibition of matrix metalloproteinase-9 (MMP-9)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.