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Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis

20 Apr 2018

Abstract excerpt

Brucella spp. are intracellular vacuolar pathogens that causes brucellosis, a worldwide zoonosis of profound importance. We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1α (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to B. melitensis and B. abortus intracellular replication. However, the mechanism by which host IRE1α regulates the...

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PMID: 29732320
DOI: 10.3389/fcimb.2018.00103

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