Article
The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells.
Infection and immunity - 1 Feb 2016
Arriola Benitez Paula Constanza, Rey Serantes Diego, Herrmann Claudia Karina, Pesce Viglietti Ayelén Ivana, Vanzulli Silvia, Giambartolomei Guillermo Hernán, Comerci Diego José, Delpino María Victoria
Abstract excerpt
The liver is frequently affected in patients with active brucellosis. In the present study, we identified a virulence factor involved in the modulation of hepatic stellate cell function and consequent fibrosis during Brucella abortus infection. This study assessed the role of BPE005 protein from B. abortus in the fibrotic phenotype induced on hepatic stellate cells during B. abortus infection in vitro and in...
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