Article

Deletion of the transcriptional regulator GntR affects apoptosis and autophagy in Brucella abortus-infected RAW 264.7 cells

2020-10-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Brucellosis is an important zoonotic disease caused by the pathogen <italic>Brucella</italic>. Regulating apoptosis and autophagy is the prerequisite for the intracellular survival of <italic>Brucella</italic>. GntR is an important transcriptional regulator of <italic>Brucella</italic> that can regulate the expression of many target genes, and then play a regula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65002cd7-dc14-534d-845e-315a8a272044
DOI: 10.21203/rs.3.rs-91178/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deletion of the transcriptional regulator GntR affects apoptosis and autophagy in Brucella abortus-infected RAW 264.7 cellsDOI 10.21203/rs.3.rs-91178/v1Read

Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type IV secretion system and quorum sensing system in macrophages.Semantic proximity Read

Analysis of Brucella melitensis wbkC protein affecting the lncRNA expression profiles of RAW264.7 cells and mining of autophagy pathway lncRNAsSemantic proximity Read

Early transcriptional responses of internalization defective Brucella abortus mutants in professional phagocytes, RAW 264.7.Semantic proximity Read

The mechanism of chronic intracellular infection with Brucella spp.Semantic proximity Read

Global gene-expression profiles of intracellular survival of the BruAb2_1031 gene mutated Brucella abortus in professional phagocytes, RAW 264.7 cells.Semantic proximity Read

Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected MacrophagesSemantic proximity Read

Brucella: functional genomics and host–pathogen interactionsSemantic proximity Read

Important biology events and pathways in Brucella infection and implications for novel antibiotic drug targets.Semantic proximity Read

An evolutionary strategy for a stealthy intracellular <i>Brucella</i> pathogenSemantic proximity Read

Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagySemantic proximity Read

A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in MacrophagesSemantic proximity Read

A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway.Semantic proximity Read