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Article

Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Gomes Marco Tulio R, Campos Priscila C, Oliveira Fernanda S, Corsetti Patricia P, Bortoluci Karina R, Cunha Larissa D, Zamboni Dario S, Oliveira Sergio C

Abstract excerpt

Pathogens are detected by innate immune receptors that, upon activation, orchestrate an appropriate immune response. Recent studies revealed the intracellular signaling cascades involved in the TLR-initiated immune response to Brucella abortus infection. However, no report has elucidated the role of inflammasome receptors in Brucella recognition. Therefore, we decided to investigate the function of NLRC4, NLRP3,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23460746
DOI: 10.4049/jimmunol.1202817

Genes

AIM2
NLRP3
NLRC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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