Article
Possible involvement of the glucocorticoid receptor (NR3C1) and selected NR3C1 gene variants in regulation of human testicular function.
Andrology - 1 Nov 2017
Nordkap L, Almstrup K, Nielsen J E, Bang A K, Priskorn L, Krause M, Holmboe S A, Winge S B, Egeberg Palme D L, Mørup N, Petersen J H, Juul A, Skakkebaek N E, Rajpert-De Meyts E, Jørgensen N
Abstract excerpt
Perceived stress has been associated with decreased semen quality but the mechanisms have not been elucidated. It is not known whether cortisol, the major stress hormone in humans, can act directly via receptors in the testis, and whether variants in the gene encoding the glucocorticoid receptor (NR3C1) can possibly modulate the effect. To address these questions, we investigated the expression of the...
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