Article
Association of DNA repair gene polymorphisms with genotoxic stress in underground coal miners.
Mutagenesis - 17 Oct 2017
Sinitsky Maxim Yu, Minina Varvara I, Asanov Maxim A, Yuzhalin Arseniy E, Ponasenko Anastasia V, Druzhinin Vladimir G
Abstract excerpt
In underground coal mining, numerous harmful substances and ionising radiation pose a major threat to the occupational safety and health of workers. Because cell DNA repair machinery eliminates genotoxic stress conferred by these agents, we examined whether single nucleotide polymorphisms in hOGG1 (rs1052133), XRCC1 (rs25487), ADPRT (rs1136410), XRCC4 (rs6869366) and LIG4 (rs1805388) genes modulate the genotoxic...