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Impact of OGG1 and PARP1 Variants on Lead and Cadmium Induced DNA Damage in Metal Handicraft Workers of Jodhpur.

Biological trace element research - 1 Jun 2026

Anjali Sudha, Kumar Kanishka, Rana Shweta, Banerjee Mithu, Purohit Purvi, Yadav Dharamveer, Sharma Praveen, Sharma Shailja

Abstract excerpt

Workers in the metal handicraft industry are frequently exposed to heavy metals such as lead and cadmium, which are known to induce oxidative DNA damage. Individual susceptibility to this damage may be influenced by genetic variations in DNA repair enzymes, particularly 8-oxoguanine DNA glycosylase 1 (OGG1) and poly(ADP-ribose) polymerase 1 (PARP1). This study examined the combined effects of metal exposure and...

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Source

Identifiers

PMID: 41410822
DOI: 10.1007/s12011-025-04942-1

Genes

OGG1
PARP1

Variants

rs1052133
rs1052133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Impact of OGG1 and PARP1 Variants on Lead and Cadmium Induced DNA Damage in Metal Handicraft Workers of Jodhpur.PMID 41410822Read ↗

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