Article

Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing

2023-12-08

Abstract excerpt

Generating animal models for individual patients within clinically-useful timeframes holds great potential toward enabling personalized medicine approaches for genetic epilepsies. The ability to rapidly incorporate patient-specific genomic variants into model animals recapitulating elements of the patient’s clinical manifestations would enable applications ranging from validation and characterization of pathogenic...

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Literature Corpus work: 5792139f-a024-5ba1-b063-a2bfc72878b4
DOI: 10.1101/2023.12.06.570164

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