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Article

Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.

Human mutation - 1 Jan 2009

Makridakis Nick M, Caldas Ferraz Lúcio Fábio, Reichardt Juergen K V

Abstract excerpt

Somatic mutations are hallmarks of cancer progression. We sequenced 26 matched human prostate tumor and constitutional DNA samples for somatic alterations in the SRD5A2, HPRT, and HSD3B2 genes, and identified 71 nucleotide substitutions. Of these substitutions, 79% (56/71) occur within a WKVnRRRnVWK sequence (a novel motif we call THEMIS [from the ancient Greek goddess of prophecy]: W=A/T, K=G/T, V=G/A/C,...

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Source

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Identifiers

PMID: 18623241
DOI: 10.1002/humu.20810
PMCID: PMC2734471

Genes

THEMIS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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