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Article

Circulating tumour DNA at baseline for individualised prognostication in patients with chemotherapy-naïve metastatic colorectal cancer. An AGEO prospective study.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2023

Bachet Jean-Baptiste, Laurent-Puig Pierre, Meurisse Aurelia, Bouché Olivier, Mas Léo, Taly Valérie, Cohen Romain, Gornet Jean-Marc, Artru Pascal, Louafi Samy, Thirot-Bidault Anne, Baumgaertner Isabelle, Coriat Romain, Tougeron David, Lecomte Thierry, Mary Florence, Aparicio Thomas, Marthey Lysiane, Blons Hélène, Vernerey Dewy, Taieb Julien

Abstract excerpt

PURPOSE: Baseline circulating tumour DNA (ctDNA) is a potential prognostic marker in metastatic colorectal cancer (mCRC) patients. However, few studies have compared ctDNA with the usual prognostic factors, and no ctDNA cut-off has been proposed for daily use in clinical practice. PATIENTS AND METHODS: Chemotherapy-naive patients with mCRC were prospectively included. Plasma samples were collected at diagnosis...

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PMID: 37390800
DOI: 10.1016/j.ejca.2023.05.022

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