Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.

doi:10.1093/carcin/bgx074

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Article

Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.

Carcinogenesis - 1 Oct 2017

Renault Anne-Laure, Mebirouk Noura, Cavaciuti Eve, Le Gal Dorothée, Lecarpentier Julie, d'Enghien Catherine Dubois, Laugé Anthony, Dondon Marie-Gabrielle, Labbé Martine, Lesca Gaetan, Leroux Dominique, Gladieff Laurence, Adenis Claude, Faivre Laurence, Gilbert-Dussardier Brigitte, Lortholary Alain, Fricker Jean-Pierre, Dahan Karin, Bay Jacques-Olivier, Longy Michel, Buecher Bruno, Janin Nicolas, Zattara Hélène, Berthet Pascaline, Combès Audrey, Coupier Isabelle, Hall Janet, Stoppa-Lyonnet Dominique, Andrieu Nadine, Lesueur Fabienne

Abstract excerpt

Recent studies have linked constitutive telomere length (TL) to aging-related diseases including cancer at different sites. ATM participates in the signaling of telomere erosion, and inherited mutations in ATM have been associated with increased risk of cancer, particularly breast cancer. The goal of this study was to investigate whether carriage of an ATM mutation and TL interplay to modify cancer risk in...

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PMID: 28981872
DOI: 10.1093/carcin/bgx074
PMCID: PMC5862273

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