Article
Cancer risks and mortality in heterozygous ATM mutation carriers.
Journal of the National Cancer Institute - 1 Jun 2005
Thompson Deborah, Duedal Silvia, Kirner Jennifer, McGuffog Lesley, Last James, Reiman Anne, Byrd Philip, Taylor Malcolm, Easton Douglas F
Abstract excerpt
BACKGROUND: Homozygous or compound heterozygous mutations in the ATM gene are the principal cause of ataxia telangiectasia (A-T). Several studies have suggested that heterozygous carriers of ATM mutations are at increased risk of breast cancer and perhaps of other cancers, but the precise risk is uncertain. METHODS: Cancer incidence and mortality information for 1160 relatives of 169 UK A-T patients (including...
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