Article
Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries.
Journal of the National Cancer Institute - 17 Jan 2001
Olsen J H, Hahnemann J M, Børresen-Dale A L, Brøndum-Nielsen K, Hammarström L, Kleinerman R, Kääriäinen H, Lönnqvist T, Sankila R, Seersholm N, Tretli S, Yuen J, Boice J D, Tucker M
Abstract excerpt
BACKGROUND: Epidemiologic studies of the families of patients with ataxia-telangiectasia (A-T), a recessive genetic neurologic disorder caused by mutation of the ATM gene, suggest that heterozygous carriers of an ATM mutation are at increased risk of cancer. A population-based study of cancer incidence in A-T families with unbiased selection and tracing of relatives would confirm this hypothesis. METHODS: We...
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