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Article

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer.

Nature reviews. Molecular cell biology - 1 Oct 2008

Lavin Martin F

Abstract excerpt

First described over 80 years ago, ataxia-telangiectasia (A-T) was defined as a clinical entity 50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer predisposition and neurodegenerative disorders and has a central role in our understanding of the DNA-damage response, signal transduction and cell-cycle control. The discovery of the protein A-T mutated (ATM) that is deficient in...

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Identifiers

PMID: 18813293
DOI: 10.1038/nrm2514

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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