Long-telomeropathy is associated with tumor predisposition syndrome

Abstract excerpt

<h4>Summary</h4> Telomeres protect chromosomal integrity, and telomere length (TL) is influenced by environmental and genetic factors. While short-telomeres are linked to rare telomeropathies, this study explored the hypothesis that a “long-telomeropathy” is associated with a cancer-predisposing syndrome. Using genomic and health data from 113,861 individuals, a trans-ancestry polygenic risk score for TL (PRS TL )...

Topics

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• Cardiovascular Diseases
• Genome-Wide Association Study
• Germ-Line Mutation
• Mendelian Randomization Analysis
• Neoplasms
• Telomere
• Telomere Homeostasis
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

13766424-5220-5b33-8b21-cac735f686fc

DOI

10.1101/2024.11.26.24318007