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Article

Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells.

The Journal of nutritional biochemistry - 1 Apr 2013

Xavier Cristina P R, Lima Cristovao F, Pedro Dalila F N, Wilson Jonathan M, Kristiansen Karsten, Pereira-Wilson Cristina

Abstract excerpt

Colorectal carcinomas (CRCs) with P53 mutations have been shown to be resistant to chemotherapy with 5-fluorouracil (5-FU), the most widely used chemotherapeutic drug for CRC treatment. Autophagy is emerging as a promising therapeutic target for drug-resistant tumors. In the present study, we tested the effects of ursolic acid (UA), a natural triterpenoid, on cell death mechanisms and its effects in combination...

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Source

Identifiers

PMID: 22841540
DOI: 10.1016/j.jnutbio.2012.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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